SNAP-25 is a SNARE protein that contributes two helices to the neuronal fusion complex, partnering with syntaxin and synaptobrevin. Lipid attachment anchors SNAP-25 to membranes despite its lack of a conventional membrane-spanning helix. Assembly helps couple recognition of a secretory carrier to membrane fusion. Its two helical contributions explain why a four-helix SNARE complex need not contain four separate protein chains. [ref]
UniProtKB by the UniProt Consortium. P60880, Function, Catalytic activity and Subunit structure
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