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1Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis by Jeff H. Tsai and othersspatiotemporal-regulation-of-epithelial-mesenchymal-transition-is-essential-for-squamous-cell-carcinoma-metastasis-by-jeff-h-tsai-and-others2026-10-202026-10-20
1Identification of the tumour transition states occurring during EMT by Ievgenia Pastushenko and othersidentification-of-the-tumour-transition-states-occurring-during-emt-by-ievgenia-pastushenko-and-others2026-10-202026-10-20
1Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance by Kari R. Fischer and othersepithelial-to-mesenchymal-transition-is-not-required-for-lung-metastasis-but-contributes-to-chemoresistance-by-kari-r-fischer-and-others2026-10-202026-10-20
1Tumor-infiltrating lymphocyte therapy or ipilimumab in advanced melanoma by Maartje W. Rohaan and otherstumor-infiltrating-lymphocyte-therapy-or-ipilimumab-in-advanced-melanoma-by-maartje-w-rohaan-and-others2026-10-202026-10-20
1TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells by Sanjeev Mariathasan and otherstgf-beta-attenuates-tumour-response-to-pd-l1-blockade-by-contributing-to-exclusion-of-t-cells-by-sanjeev-mariathasan-and-others2026-10-202026-10-20
1Mutations associated with acquired resistance to PD-1 blockade in melanoma by Jesse M. Zaretsky and othersmutations-associated-with-acquired-resistance-to-pd-1-blockade-in-melanoma-by-jesse-m-zaretsky-and-others2026-10-202026-10-20
1Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2 by Richard A. Morgan and otherscase-report-of-a-serious-adverse-event-following-the-administration-of-t-cells-transduced-with-a-chimeric-antigen-receptor-recognizing-erbb2-by-richard-a-morgan-and-others2026-10-202026-10-20
1Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes by F. William Studier and othersuse-of-bacteriophage-t7-rna-polymerase-to-direct-selective-high-level-expression-of-cloned-genes-by-f-william-studier-and-others2026-10-202026-10-20
1Molecular structure of a left-handed double helical DNA fragment at atomic resolution by A. H.-J. Wang and othersmolecular-structure-of-a-left-handed-double-helical-dna-fragment-at-atomic-resolution-by-a-h-j-wang-and-others2026-10-202026-10-20
1Sequence-specific recognition of double helical nucleic acids by proteins by Nadrian C. Seeman and otherssequence-specific-recognition-of-double-helical-nucleic-acids-by-proteins-by-nadrian-c-seeman-and-others2026-10-202026-10-20
1A mediator required for activation of RNA polymerase II transcription in vitro by Peter M. Flanagan and othersa-mediator-required-for-activation-of-rna-polymerase-ii-transcription-in-vitro-by-peter-m-flanagan-and-others2026-10-202026-10-20
1Structural basis of transcription activation: the CAP-alpha CTD-DNA complex by Brian Benoff and othersstructural-basis-of-transcription-activation-the-cap-alpha-ctd-dna-complex-by-brian-benoff-and-others2026-10-202026-10-20
1Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression by Wade Winkler and othersthiamine-derivatives-bind-messenger-rnas-directly-to-regulate-bacterial-gene-expression-by-wade-winkler-and-others2026-10-202026-10-20
1FourU: a novel type of RNA thermometer in Salmonella by Torsten Waldminghaus and othersfouru-a-novel-type-of-rna-thermometer-in-salmonella-by-torsten-waldminghaus-and-others2026-10-202026-10-20
1Characterization of Proteins by Size-Exclusion Chromatography Coupled to Multi-Angle Light Scattering (SEC-MALS) by Daniel Some and otherscharacterization-of-proteins-by-size-exclusion-chromatography-coupled-to-multi-angle-light-scattering-sec-mals-by-daniel-some-and-others2026-10-202026-10-20
1Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide by Keqin Chen and otherstuning-the-activity-of-an-enzyme-for-unusual-environments-sequential-random-mutagenesis-of-subtilisin-e-for-catalysis-in-dimethylformamide-by-keqin-chen-and-others2026-10-202026-10-20
1Kemp elimination catalysts by computational enzyme design by Daniela Röthlisberger and otherskemp-elimination-catalysts-by-computational-enzyme-design-by-daniela-rothlisberger-and-others2026-10-202026-10-20
1Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression by A. De Vos and othershuman-and-rat-beta-cells-differ-in-glucose-transporter-but-not-in-glucokinase-gene-expression-by-a-de-vos-and-others2026-10-202026-10-20
1Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation by Benjamin Glaser and othersfamilial-hyperinsulinism-caused-by-an-activating-glucokinase-mutation-by-benjamin-glaser-and-others2026-10-202026-10-20
1The Sequential Inactivation of Glycogen Phosphorylase and Activation of Glycogen Synthetase in Liver after the Administration of Glucose to Mice and Rats by Willy Stalmans and othersthe-sequential-inactivation-of-glycogen-phosphorylase-and-activation-of-glycogen-synthetase-in-liver-after-the-administration-of-glucose-to-mice-and-rats-by-willy-stalmans-and-others2026-10-202026-10-20

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Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact
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