This isotope separation method was the first big successful method, having been used in the Manhattan Project, notably in the K-25 reactor.
This method was superseded by the more efficient gas centrifuges.
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Isotope separation is the process of separating isotopes of a chemical element from each other. Isotopes are atoms of the same element that have the same number of protons but different numbers of neutrons, resulting in different atomic masses. For example, uranium has several isotopes, including uranium-235 and uranium-238, which have significant differences in their properties and uses, particularly in nuclear power and weapons.