Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

First sequenced variant: www.ncbi.nlm.nih.gov/genome/?term=86693

Genes at: www.ncbi.nlm.nih.gov/nuccore/MN908947.3 TODO protein list on a database?

30kbp, 10 genes, 29 proteins: cen.acs.org/biological-chemistry/infectious-disease/know-novel-coronaviruss-29-proteins/98/web/2020/04

50-200 nanometers in diameter.

Gene overview:

www.youtube.com/watch?v=6DxlkxA82FM COVID-19 Symposium: Entry of Coronavirus into Cells | Dr. Paul Bates

Interaction points:

Genes list: www.ncbi.nlm.nih.gov/nuccore/MN908947.3

Some are named after the encoded protein. Others that are not as clean are just orfXXX for open reading frame XXX.

Largest gene, polyprotein that contains SARS-CoV-2 non-structural proteins 1 to 11.

Envelope.

As shown at pubmed.ncbi.nlm.nih.gov/16877062/#&gid=article-figures&pid=fig-3-uid-2 has transmembrane domain.

Membrane.

As shown at pubmed.ncbi.nlm.nih.gov/16877062/#&gid=article-figures&pid=fig-3-uid-2 has transmembrane domain.

Spike.

Nucleocapsid phosphoprotein, sticks to the RNA inside.

www.nature.com/articles/s41467-020-20768-y mentions functions:

These are also required for test tube replication.

Mentioned at: cen.acs.org/biological-chemistry/infectious-disease/know-novel-coronaviruss-29-proteins/98/web/2020/04

Protease that cuts up ORF1ab. Note that it is also present in ORF1ab.

The RdRp, since this is a Positive-strand RNA virus.

Unlike SARS-CoV-2 non-structural protein, these are not needed for test tube reproduction. They must therefore be for host modulation.