www.youtube.com/watch?v=6DxlkxA82FM COVID-19 Symposium: Entry of Coronavirus into Cells | Dr. Paul Bates
Model of Membrane Fusion by SARS CoV-2 Spike Protein by clarafi (2020)
. Source. Genes list: www.ncbi.nlm.nih.gov/nuccore/MN908947.3
Some are named after the encoded protein. Others that are not as clean are just orfXXX for open reading frame XXX.
Largest gene, polyprotein that contains SARS-CoV-2 non-structural proteins 1 to 11.
Envelope.
As shown at pubmed.ncbi.nlm.nih.gov/16877062/#&gid=article-figures&pid=fig-3-uid-2 has transmembrane domain.
Membrane.
As shown at pubmed.ncbi.nlm.nih.gov/16877062/#&gid=article-figures&pid=fig-3-uid-2 has transmembrane domain.
Spike.
Nucleocapsid phosphoprotein, sticks to the RNA inside.
www.nature.com/articles/s41467-020-20768-y mentions functions:
- helps pack the viral RNA into the capsule
- also has a side function in immune suppression
These are also required for test tube replication.
Mentioned at: cen.acs.org/biological-chemistry/infectious-disease/know-novel-coronaviruss-29-proteins/98/web/2020/04
The RdRp, since this is a Positive-strand RNA virus.
Unlike SARS-CoV-2 non-structural protein, these are not needed for test tube reproduction. They must therefore be for host modulation.
Articles by others on the same topic (0)
There are currently no matching articles.