The following things come to mind when you look into research in this area, especially the search for BB(5) which was hard but doable:
Turing machine acceleration refers to using high level understanding of specific properties of specific Turing machines to be able to simulate them much fatser than naively running the simulation as usual.
Acceleration allows one to use simulation to find infinite loops that might be very long, and would not be otherwise spotted without acceleration.
The last value we will likely every know for the busy beaver function! BB(6) is likely completely out of reach forever.
By 2023, it had basically been decided by the The Busy Beaver Challenge as mentioned at: discuss.bbchallenge.org/t/the-30-to-34-ctl-holdouts-from-bb-5/141, pending only further verification. It is going to be one of those highly computational proofs that will be needed to be formally verified for people to finally settle.
As that project beautifully puts it, as of 2023 prior to full resolution, this can be considered the:
simplest open problem in mathematics
on the Busy beaver scale.
Best busy beaver machine known since 1989 as of 2023, before a full proof of all 5 state machines had been carried out.
Paper extracted to HTML by Heiner Marxen: turbotm.de/~heiner/BB/mabu90.html
Non formal proof with a program March 2023: www.sligocki.com/2023/03/13/skelet-1-infinite.html Awesome article that describes the proof procedure.
The proof uses Turing machine acceleration to show that Skelet machine #1 is a Translated cycler Turing machine with humongous cycle paramters:
  • start between 50-200 M steps, not calculated precisely on the original post
  • period: ~8 billion steps
Project trying to compute BB(5) once and for all. Notably it has better presentation and organization than any other previous effort, and appears to have grouped everyone who cares about the topic as of the early 2020s.
Very cool initiative!
By 2023, they had basically decided every machine: discuss.bbchallenge.org/t/the-30-to-34-ctl-holdouts-from-bb-5/141