Organization of epithelial cells into distinct apical and basolateral domains. Individual apical identity and coordination of apical surfaces into a shared tissue lumen are related but distinct properties.
Basolateral polarity regulators including Scribble, Discs large and Lethal giant larvae. Their interactions oppose inappropriate apical-domain expansion while supporting other tissue-specific functions.
Apical-domain regulators organized around Crumbs-family proteins and associated scaffolds. Tissue-specific interactions and dosage influence apical membrane organization.
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