A spatial asymmetry of cellular organisation, including distinct apical and basal domains, that can influence division, signalling and lineage allocation.
Growth concentrated at a selected part of the biological cell surface. Spatial selection can be controlled at transport, vesicle docking or fusion rather than only by directed vesicle motion.
Coordinated asymmetry within the plane of a tissue, distinct from the apical-basal axis. Not every case of planar polarization uses the same molecular pathway.
A group of interacting polarity regulators including PAR-3, PAR-6 and atypical protein kinase C. Its organization links cortical domains to junctional and morphogenetic behaviour.
Organization of epithelial cells into distinct apical and basolateral domains. Individual apical identity and coordination of apical surfaces into a shared tissue lumen are related but distinct properties.
Basolateral polarity regulators including Scribble, Discs large and Lethal giant larvae. Their interactions oppose inappropriate apical-domain expansion while supporting other tissue-specific functions.
Apical-domain regulators organized around Crumbs-family proteins and associated scaffolds. Tissue-specific interactions and dosage influence apical membrane organization.
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