Barry M. Brenner was a researcher in kidney physiology who helped make the physical forces driving glomerular filtration directly accessible to experiment. In 1971, Barry M. Brenner and collaborators studied rats whose glomeruli lay at the exposed surface of the kidney. This anatomical feature let them place pressure-measuring micropipettes inside glomerular capillaries, rather than infer their pressure only from upstream arterial measurements.[ref]
The Dynamics of Glomerular Ultrafiltration in the Rat by Barry M. Brenner and others. Byline and Abstract: surface-glomerulus Wistar rats and servo-nulling micropipette transducers
The team combined hydrostatic pressure measurements with oncotic pressure estimates and measurements of filtration by individual nephrons. These quantities describe different parts of the mechanism: a pressure difference can drive water across the glomerular filtration barrier, while the concentration of retained plasma proteins opposes that movement. Raising pressure in the receiving compartment can therefore reduce filtration without changing arterial pressure. Connecting these separately measurable quantities made the experiment a test of a physical explanation of kidney function.[ref]
The Dynamics of Glomerular Ultrafiltration in the Rat by Barry M. Brenner and others. Abstract: proximal-tubular pressures, plasma colloid-osmotic pressures and single-nephron filtration; qualitative conclusions only, in view of the linked October 1971 correction
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