An AlphaFold confidence score for local structural accuracy, usually reported on a 0–100 scale. It is not a probability that a complete structure is correct.
Expected positional error at one residue after predicted and true structures are aligned on another residue. Low within-domain values with high between-domain values support more confident internal geometry than relative domain placement. PAE is not a physical residue–residue distance and need not be symmetric.[ref]
PAE: A measure of global confidence in AlphaFold2 predictions by EMBL-EBI. Formal definition and interpretation of inter-domain confidence
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Bioinformatics is an interdisciplinary field that combines biology, computer science, mathematics, and statistics to analyze and interpret biological data. It plays a crucial role in managing and understanding the vast amounts of information generated by modern biological research, particularly in areas such as genomics, proteomics, and molecular biology.
