POP-1 2026-10-20
The Caenorhabditis elegans TCF-family transcription factor. Its action depends on nuclear abundance and availability of SYS-1, so it can repress or activate endoderm targets in different daughter cells.
PRG-1 2026-10-20
The Caenorhabditis elegans Piwi-family protein associated with 21U piRNAs and germline surveillance of RNA expression.
SKN-1 2026-10-20
A maternal transcription factor providing endomesodermal input to the EMS lineage in Caenorhabditis elegans. Its effects include activation of MED factors and endoderm-specifying regulators.
SYS-1 2026-10-20
A divergent Caenorhabditis elegans beta-catenin coactivator that binds POP-1. A high SYS-1-to-POP-1 ratio supports transcriptional activation in the appropriate posterior daughter.
Wnt-beta-catenin asymmetry pathway 2026-10-20
A signalling system that produces different transcriptional states in sister cells. In the Caenorhabditis elegans EMS division, nuclear POP-1 and SYS-1 levels establish different coactivator-to-transcription-factor ratios.