Carla P. Concepcion investigated whether the miR-34 family is necessary for p53-dependent responses. Deletion of the family in the studied house mouse models left major p53 responses intact, distinguishing the necessity of an endogenous regulator from the effects of artificially increasing its expression.[ref]
Intact p53-dependent responses in miR-34-deficient mice by Carla P. Concepcion and others. 2012, Discussion: complete miR-34 deletion, intact p53 pathway and necessity versus sufficiency
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