A chain map is a family satisfying .
A chain map inducing isomorphisms on all homology groups. The same definition applies to a map of cochain complexes using cohomology groups. A quasi-isomorphism need not be an isomorphism in each degree.
Let be a chain map between degreewise finitely generated free abelian groups. If its reduction modulo every prime number is a quasi-isomorphism, the mapping cone acyclicity criterion makes acyclic. The short exact sequence of chain complexes implies that multiplication by is an isomorphism on every . These are finitely generated abelian groups. Their free summands would make multiplication by fail to be surjective, and any nonzero finite summand would make it fail to be injective for a prime dividing its order. Thus and is a quasi-isomorphism. Degreewise finite generation is essential to this argument.
A chain map sends cycles to cycles and boundaries to boundaries, and therefore induces by .
Chain maps are chain homotopic when there are maps such that
Chain-homotopic maps induce the same map on homology.
A contracting homotopy on a chain complex is a degree-one map whose displayed identity makes the identity chain-homotopic to zero. It implies that all homology vanishes. The converse is not valid for arbitrary complexes of modules.
For cochain maps , a cochain homotopy is a family satisfying
Cochain-homotopic maps induce the same map on cohomology.
For an open cover of , singular chains generated by simplices lying inside one member of form a subcomplex chain-homotopy equivalent to the full singular chain complex. Repeated barycentric subdivision makes chains small.

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