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An antifungal drug inhibits fungal growth or damages fungal cells. Different classes act on membrane sterols, cell-wall synthesis or cell division. The target helps explain both the range of susceptible organisms and limits of selectivity.^[ref]

Fluconazole is an azole antifungal drug that interferes with fungal sterol synthesis. Changes in the target enzyme or access to the target can contribute to resistance. A susceptible species name therefore does not guarantee susceptibility of every isolate.^[ref]

Nystatin is a polyene antifungal drug that disrupts fungal membranes. Its action differs from inhibition of cell-wall synthesis, illustrating how drugs against the same organism can attack different cellular structures.^[ref]

Terbinafine is an antifungal drug inhibiting squalene epoxidase. Interference with sterol metabolism changes the fungal membrane system and promotes accumulation of precursor material.^[ref]