An initiation-factor scaffold participating in assembly of eIF4F.
By binding other initiation components, it helps connect recognition of a capped message to recruitment of the biological translation machinery. The scaffold function explains how cleavage or sequestration of eIF4G can alter biological translation even without changing the sequence of the message. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 4–7, chromatin, replication and gene regulation
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