An enzyme that removes particular histone methyl marks.
Different demethylases act on different residues and methylation states, so removal of H3K4 methylation and removal of H3K27 trimethylation are distinct activities. Regulated removal makes a chromatin mark reversible without requiring replacement of the underlying DNA sequence. [ref]
An Arabidopsis thaliana H3K27 demethylase involved in resetting FLC after vernalization.
Removing repressive methylation helps restore expression competence after an environmental-history-dependent state. The example connects enzymatic reversal of a histone modification to resetting a developmental response between generations. [ref]

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