An embryonic appendage precursor whose growth, signalling and cellular contributions can be compared between forelimbs and hindlimbs.
The distal limb region including wrist or ankle elements and digits.
The intermediate limb region containing the radius and ulna, or tibia and fibula, in familiar tetrapod limbs.
The proximal limb region containing the humerus or femur in familiar tetrapod limbs.
A classical model in which time spent in a distal region of the growing limb contributes to proximal-distal specification. Experimental support must be distinguished from alternative consequences of altered survival and growth.
A specialized distal ectodermal structure that supplies signals supporting limb outgrowth and patterning. Removing it simultaneously alters several processes, so truncation alone does not uniquely identify a timing mechanism.
A posterior limb-bud signalling region involved in anterior–posterior patterning. The fate of its labelled cells and the identities of adjacent anatomical digits are related but distinct observations.
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