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Clyde Cowan, Frederick Reines and collaborators tested whether a particle produced by a nuclear reactor could interact again after leaving its source. At Savannah River, water targets containing cadmium chloride lay between liquid scintillators. Opposite detectors recorded prompt positron annihilation gamma rays; Neutron moderation preceded delayed neutron capture signals in cadmium. The arrangement used two target layers and three scintillator layers, with the middle scintillator shared.^[ref]

The original functional diagram separates the two signal mechanisms and their timing. It omits dimensions and phototube counts, and is not a reproduction of a historical drawing. The measured objects are detector pulses; identifying their common cause also requires calibration and background tests.

The 1956 paper describes positron-source and neutron-source calibrations, pulse-height gates and photographic pulse records. Diluting the target with heavy water halved the proton density and reactor signal while preserving neutron-detection efficiency. Changing the cadmium concentration altered capture timing; removing it removed the reactor signal. Added shielding tested competing external radiation. These interventions tested the reaction's ingredients, beyond simply observing a reactor-dependent count rate.^[ref]

Place a far detector near the first atmospheric disappearance maximum, approximately $1.2\mathrm{km}$ for the source's monochromatic energy and splitting, and a nearly identical near detector a few hundred metres from the reactor complex. Their flux-corrected comparison largely cancels reactor power, emitted-spectrum and absolute-efficiency uncertainties. For a broad reactor spectrum one fits energy-dependent disappearance instead of treating that single baseline as a universal exact optimum.

Detect ${\bar{\nu }}_{e}p\to e^{+}n$ in a hydrogen-rich target, for example liquid scintillator with neutron-capture enhancement. The prompt Positron signal estimates neutrino energy; the delayed neutron-capture signal supplies a time-and-position coincidence that strongly reduces random backgrounds. Use sufficient target mass and exposure, low radioactivity, overburden and a muon veto to reduce cosmogenic backgrounds, calibrated relative energy response and efficiency, and monitored reactor powers and baselines. Account for multiple reactor cores, spent-fuel backgrounds and accidental coincidences. At kilometre baselines the slow solar phase is small, so the disappearance depth directly probes ${\sin }^2(2{\theta }_{13})$ with little sensitivity to the CP phase or mass ordering.