METTL3

METTL3 is a catalytic component of a protein complex that deposits N6-methyladenosine on RNA, especially messenger RNA. It works with METTL14 and regulatory components rather than determining every cellular methylation site in isolation. Modification can affect RNA processing, stability or biological translation through proteins that recognize the mark. The effect of a METTL3 perturbation therefore depends on which transcripts and readers are present. ^[ref]