For parameter of interest , constrained nuisance fit , and suitable ancillary sample coordinates , this adjustment includes both nuisance observed information and a sample-space Jacobian determinant. The derivative holds fixed. Implicit differentiation of the constrained nuisance score function gives the equivalent expression . The semicolon distinguishes data-coordinate differentiation from parameter differentiation. Omitting the Jacobian requires an additional justified simplification; the information adjustment alone is not universal.
For independent Inverse Gaussian distributions with shape and mean , the constrained and full nuisance maximum-likelihood estimates both equal , giving a unit sample-coordinate Jacobian determinant. The nuisance observed information there is . Hence subtracting half its logarithm from the profile log-likelihood replaces the coefficient of by . For a nonconstant sample the modified fit is .
For independent exponential distributions with means and a nonconstant fixed design, put . The constrained maximum-likelihood estimate is and the profile log-likelihood is . Use the ancillary statistic to specify sample coordinates. At fixed , the Jacobian determinant , while . Therefore the modified profile likelihood satisfiesThe adjustment is independent of . Keeping only the observed information adjustment would miss this cancellation.
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