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In units with $\hslash =1$, the inverse lifetime of an unstable particle. A neutral meson mixing effective Hamiltonian operator incorporates decay through its anti-Hermitian part $-i\Gamma /2$.

Let $|1⟩=|D^0⟩$, $|2⟩=|{\bar{D}}^0⟩$. In the rest frame, the CPT theorem interchanges these states up to irrelevant phases. For the weak Hamiltonian operator $H^{\prime }$, with $H^{\prime }=H^{\prime †}$, and its antiunitary CPT symmetry operator $\Theta$,Its diagonal matrix elements are real by Hermitian conjugation, soIn the specified phase convention, the CP symmetry operator on this two-state subspace is $-{\sigma }_x$. If the weak interaction preserves CP symmetry, ${\sigma }_{x}R{\sigma }_x=R$, givingIndependently, Hermitian conjugation gives $R_{21}=R_{12}^{\ast }$ for this $H^{\prime }$. Hence CP symmetry makes the off-diagonal element real in this convention; that conjugation relation alone does not imply CP symmetry.

For neutral meson mixing described by the decay-effective Hamiltonian operator $R=M-i\Gamma /2$, the effective matrix is generally not a Hermitian matrix. The CPT constraints on neutral-meson mixing still give equality of the complex diagonal entries, expressing equal masses and total decay widths, and CP symmetry gives equality of the off-diagonal entries in the specified convention. One must not additionally impose $R_{21}=R_{12}^{\ast }$ on this decay-effective matrix.