For a stable one-species linear noise approximation, the normalized stationary fluctuation-dissipation relation for a reaction network becomesTo see the factors explicitly, the linearized restoring rate is , while the chemical noise intensity is the rate-weighted squared step sizeStationarity of the variance gives . Using therefore yieldsThis is the stationary fluctuation result within the stated negligible-fluctuation/linear-noise approximation, not an exact identity for the boundary-corrected discrete chemistry.
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