Past exam of the mathematics course of the University of Cambridge / 2017 / iii / Paper 338 / 3 / c / iii

For $k=m/2$ independent reads in each sum, read noise contributes $k{r}^2/g^2$ in squared ADU units. HenceUsing the shot-noise-only formula therefore givesThe condition for negligible contamination is $gN\gg k{r}^2$, equivalently a large number of collected electrons per individual frame compared with $r^2$. Summing more identical-level frames does not change that ratio because both $N$ and the read variance scale with $k$. Measure read noise from paired bias images, or fit mean versus noise variance across several illumination levels: the shot-noise slope determines detector gain, while the read term gives an intercept. If $r$ is known, the corrected positive solution satisfies $E^2{N}^2{g}^2-2Ng-2k{r}^2=0$. Offset subtraction removes the mean bias but not the read variance. Correlated read errors need a different covariance calculation.