Past exam of the mathematics course of the University of Oxford / Undated / Prelims / Mathematics III resit / 7 / b / iv

They need not be independent. For a counterexample take $n=2$, $x_1=-1$, $x_2=1$, and independent errors taking $-1,1$ with equal probability. ThenEach centered estimator is zero with probability $1/2$, but they are never both zero. Their zero events therefore violate independence.

A sufficient additional assumption is that the errors have a common normal distribution. The two estimators are then Jointly Gaussian, being linear combinations of the independent Gaussian random variables. Their zero covariance, established in iii, implies independence of uncorrelated jointly normal variables. Normal errors are a sufficient condition here, not a claim that no other error probability distribution could ever work.