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Joined 2026-09-21 Message
Incoming links: PDGFR
PDGFR is a receptor tyrosine kinase; its key ligand-induced autophosphorylation is on tyrosine residues. Ras-PST25 recognizes phosphorylated serine residues and threonine residues, so it is not the appropriate reagent to detect the characteristic activated PDGFR phosphotyrosines. Use a phosphotyrosine or validated phospho-PDGFR antibody, ideally alongside total PDGFR. The larger receptor may also require a different gel and transfer range, but changing the size range alone would not correct the epitope mismatch.
Platelet-derived growth factor 2026-11-05
PDGF means platelet-derived growth factor, a family of signaling protein ligands for PDGFR. Members form protein dimers, including the classical AA, AB and BB combinations.[ref]
Classification of Growth Factors and Their Receptors by Anna Bafico and Stuart A. Aaronson. Platelet-Derived Growth Factor Family: A and B chains and the three classical dimer combinations
Ligand binding can bring two receptors together and activate their receptor tyrosine kinase activity.[ref]Platelet-derived growth factor receptor in MeSH. Descriptor D017479: alpha and beta receptor types and ligand-induced receptor dimerization
Release from platelets links PDGF to local tissue responses after injury. Nearby connective-tissue cells can respond by entering cell proliferation.[ref]
Platelet-derived growth factor in MeSH. Descriptor D010982: platelet release and initiation of connective-tissue-cell replication