A prion disease is associated with self-propagating abnormal folding of a protein. Its epidemiological interpretation requires distinguishing exposure, infection, clinical onset and diagnostic detection.
A human prion disease associated with exposure to the BSE agent. Exposure totals and clinical-onset totals measure different stages of the disease process; incubation periods and ascertainment affect their relationship.
A prion disease of sheep and goats. A scrapie test result and a BSE diagnosis are distinct outcomes, even when the clinical appearances overlap.
A prion disease of cattle. A positive surveillance test is an observed diagnostic outcome, whose frequency need not equal true infection prevalence unless test performance and sampling are accounted for.
Articles by others on the same topic
There are currently no matching articles.