Robert E. Goldsby investigated the consequences of defective DNA polymerase proofreading in house mouse models. The reported increase in epithelial cancers connected a molecular mechanism for copying fidelity with tumour development in the studied animals.[ref]
High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading by Robert E. Goldsby and others. 2002, abstract: DNA polymerase-delta proofreading deficiency and epithelial cancer incidence
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