Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride by Qingpin Xiao and others (2020, 10.1038/s41467-020-19249-z)

Nature Communications 11, 5430. The NADP–dihydrofinasteride structure, mutant assays and modeled testosterone placement provide complementary evidence; a trapped inhibitor is not a directly observed testosterone transition state.