CLI hello world:
gnuplot -p -e 'p sin(x)'reconstruction/ecoli/flat/condition/nutrient/minimal.tsvcontains the nutrients in a minimal environment in which the cell survives:If we compare that to"molecule id" "lower bound (units.mmol / units.g / units.h)" "upper bound (units.mmol / units.g / units.h)" "ADP[c]" 3.15 3.15 "PI[c]" 3.15 3.15 "PROTON[c]" 3.15 3.15 "GLC[p]" NaN 20 "OXYGEN-MOLECULE[p]" NaN NaN "AMMONIUM[c]" NaN NaN "PI[p]" NaN NaN "K+[p]" NaN NaN "SULFATE[p]" NaN NaN "FE+2[p]" NaN NaN "CA+2[p]" NaN NaN "CL-[p]" NaN NaN "CO+2[p]" NaN NaN "MG+2[p]" NaN NaN "MN+2[p]" NaN NaN "NI+2[p]" NaN NaN "ZN+2[p]" NaN NaN "WATER[p]" NaN NaN "CARBON-DIOXIDE[p]" NaN NaN "CPD0-1958[p]" NaN NaN "L-SELENOCYSTEINE[c]" NaN NaN "GLC-D-LACTONE[c]" NaN NaN "CYTOSINE[c]" NaN NaNreconstruction/ecoli/flat/condition/nutrient/minimal_plus_amino_acids.tsv, we see that it adds the 20 amino acids on top of the minimal condition:so we guess that"L-ALPHA-ALANINE[p]" NaN NaN "ARG[p]" NaN NaN "ASN[p]" NaN NaN "L-ASPARTATE[p]" NaN NaN "CYS[p]" NaN NaN "GLT[p]" NaN NaN "GLN[p]" NaN NaN "GLY[p]" NaN NaN "HIS[p]" NaN NaN "ILE[p]" NaN NaN "LEU[p]" NaN NaN "LYS[p]" NaN NaN "MET[p]" NaN NaN "PHE[p]" NaN NaN "PRO[p]" NaN NaN "SER[p]" NaN NaN "THR[p]" NaN NaN "TRP[p]" NaN NaN "TYR[p]" NaN NaN "L-SELENOCYSTEINE[c]" NaN NaN "VAL[p]" NaN NaNNaNin theupper moundlikely means infinite.We can try to understand the less obvious ones:ADP: TODOPI: TODOPROTON[c]: presumably a measure of pHGLC[p]: glucose, this can be seen by comparingminimal.tsvwithminimal_no_glucose.tsvAMMONIUM: ammonium. This appears to be the primary source of nitrogen atoms for producing amino acids.CYTOSINE[c]: hmmm, why is external cytosine needed? Weird.
reconstruction/ecoli/flat/reconstruction/ecoli/flat/condition/timeseries/contains sequences of conditions for each time. For example:reconstruction/ecoli/flat/reconstruction/ecoli/flat/condition/timeseries/000000_basal.tsvcontains:which means just using"time (units.s)" "nutrients" 0 "minimal"reconstruction/ecoli/flat/condition/nutrient/minimal.tsvuntil infinity. That is the default one used byrunSim.py, as can be seen from./out/manual/wildtype_000000/000000/generation_000000/000000/simOut/Environment/attributes/nutrientTimeSeriesLabelwhich contains just000000_basal.reconstruction/ecoli/flat/reconstruction/ecoli/flat/condition/timeseries/000001_cut_glucose.tsvis more interesting and contains:so we see that this will shift the conditions half-way to a condition that will eventually kill the bacteria because it will run out of glucose and thus energy!"time (units.s)" "nutrients" 0 "minimal" 1200 "minimal_no_glucose"
Timeseries can be selected with--variant nutrientTimeSeries X Y, see also: run variants.We can use that variant with:VARIANT="condition" FIRST_VARIANT_INDEX=1 LAST_VARIANT_INDEX=1 python runscripts/manual/runSim.pyreconstruction/ecoli/flat/condition/condition_defs.tsvcontains lines of form:"condition" "nutrients" "genotype perturbations" "doubling time (units.min)" "active TFs" "basal" "minimal" {} 44.0 [] "no_oxygen" "minimal_minus_oxygen" {} 100.0 [] "with_aa" "minimal_plus_amino_acids" {} 25.0 ["CPLX-125", "MONOMER0-162", "CPLX0-7671", "CPLX0-228", "MONOMER0-155"]conditionrefers to entries inreconstruction/ecoli/flat/condition/condition_defs.tsvnutrientsrefers to entries underreconstruction/ecoli/flat/condition/nutrient/, e.g.reconstruction/ecoli/flat/condition/nutrient/minimal.tsvorreconstruction/ecoli/flat/condition/nutrient/minimal_plus_amino_acids.tsvgenotype perturbations: there aren't any in the file, but this suggests that genotype modifications can also be incorporated heredoubling time: TODO experimental data? Because this should be a simulation output, right? Or do they cheat and fix doubling by time?active TFs: this suggests that they are cheating transcription factors here, as those would ideally be functions of other more basic inputs
My Job is to Open and Close Doors by Mattias Pilhede (2019)
Source. An interesting humorous short meditation on common sense.Starting at tx cbbaa0a64924fe1d6ace3352f23242aa0028d4e0ff6ae8ed615244d66079cfb1 (2011-08-05), Catholic Bitcoin developer Luke Dashjr started to inscribe prayers in the miner messages of his mining pool "Eligius pool", usually one verse per message.
These are some of the earliest inscriptions in the blockchain, and therefore extremelly visible.
Although the prayer verses appear contiguous in ASCII dumps, Eligius was not actually mining every block: it is just that in those early days, miners still hadn't started adding advertisement messages to every block, so only Eligius shows up and appears contiguous.
At some point, opponents noticed these messages, and started adding atheist mockery graffiti replies, which appear interspersed in ASCII dumps with the prayer.
The first prayer is the Latin version of the Divine Praises, a Catholic prayer composed in 1797 in Italian by Luigi Felici for the purpose of making reparation after saying or hearing sacrilege or blasphemy. Luke claims he was referring to anything in particular that came prior in the blockchain: twitter.com/LukeDashjr/status/1749182637569122434. There arent many earlier inscriptions at all to refer to in any case! The prayer and correspondong interrupts (in transaction outputs, not by other miners) ordered by block are:
- 139690 (2011-08-05) prayer: "Eligius/Benedictus Deus. Benedictum Nomen Sanctum eius."
- 139717 prayer: "Eligius/Benedictus Deus. Benedictum Nomen Sanctum eius.'
- 139758 interruption:
***************************************************. This is not a Coinbase message: www.blockchain.com/explorer/transactions/btc/23befff6eea3dded0e34574af65c266c9398e7d7d9d07022bf1cd526c5cdbc94. This Bitcoin input script appears to spend a standard P2PKH output, but it first adds an extra value to the stack which contains the***. - 139792 prayer: "Benedictus Iesus Christus, verus Deus et verus homo.'
- 139831 prayer: "Benedictum Nomen Iesu.'
- 139838 (2011-08-06) interruption: "I LIKE TURTLES" (tx 78eb16507b3d3df615e3b474e853db4667f4b11954ec6d918b1ded0fca7ad25a)
- 138898 prayer: "Benedictum Cor eius sacratissimum."
- 139904 prayer: "Benedictus Sanguis eius pretiosissimus."
- 139921 prayer: "Benedictus Iesus in sanctissimo altaris Sacramento."
- 139942 prayer: "Benedictus Sanctus Spiritus, Paraclitus."
- 139954 interrupion: "aC-C-C-COMBO BREAKER" (tx 138c024a76df99ecafd2236d5429cf574b7778a3c6508bd83f116c832f3c6980)
- 139960 prayer: "Benedictus Sanctus Spiritus, Paraclitus."
- 139977 prayer: "Benedicta excelsa Mater Dei, Maria sanctissima."
- 139990 (2011-08-06) prayer: "Benedicta sancta eius et immaculata Conceptio."
Then comes:and various others + output message interruptions.
- 140181 Latin Trinitarian formula
In nomine Patris et Filii et Spiritus Sancti. Amen.
- Act of Contrition
- Act of Hope
Then at last come the first miner message interruptions. Luke explained on Twitter[ref] that they were also made by Eligius pool, as there was a system in which contributors besides Luke could submit their own strings:followed by more prayers and interruptions such as tx ec92d245822fa1ff862f3314b9102f36fe1eb8bc055865674c75323540aedef6:
- 142547: (2011-08-25) tx 8e1e44a48b5e79636675d1476f8e4add075bbeb7f49e00ec743eed56f17feaaa A yandere game is starting in 60 seconds! Please type "]yandere" to join. Yandere Simulator comes to mind, but it can't be because that was pitched 2014.
- 142550: "A yandere game is starting in 60 seconds! Please type "]yandere" to join."
- 142573: (2011-08-25) "Militant atheists, bit.ly/naNhG2 -- happy now?". A Rickrolling link. Perhaps one of the fist.
- 142596: (2011-08-25) "<cjdelisle> ran out of prayers?! That explains the price drop.". Possibly quoting this dude on som twitter.com/cjdelisle Bitcoin IRC channel givesn the
<USERNAME>format? - 142640: "an de ti go su by ra me ni ko hu vy la po fy ton": Tonal system numerals. Interesting.
The last Luke prayer appears to be on block 143822 (2011-09-03)
... the Lord of the harvest, that he send forth labourers into his harvest.
Then there is a bit of radio silence, until finally Slush Pool started self advertising for the first time on block 163970 (2012-01-26):They had been mining for a long time by then (December 2010 according to en.bitcoin.it/wiki/Slush_Pool), but this is when they decided to add a human readable ASCII message as well.
/P2SH/BIP16/slush/R,From then on, miner messages would be forever polluted with ads, and Luke's multi-miner message feat would never again be reproduced.
The non-obvious interruptions are all well known memes/anime references:
- "I like turtles": knowyourmeme.com/memes/i-like-turtles
- Combo breaker: knowyourmeme.com/memes/combo-breaker
- "Yukkuri Shiteitte ne": knowyourmeme.com/memes/yukkuri-shiteitte-ne
- "kLhLUKE-JR IS A Pedophile! Oh, and God isn't real, sucka. Stop polluting the blockchain with your nonsense.", tx 9740e7d646f5278603c04706a366716e5e87212c57395e0d24761c0ae784b2c6, block 141460
- "Help me, ERINNNNNN!!": touhou.fandom.com/wiki/Lyrics:_Help_me,_ERINNNNNN!!
- "EASY MODO? How lame!F?": knowyourmeme.com/memes/kimoi-girls
Bibliography:
- 2011-08-19 bitcointalk.org/index.php?topic=38007.0 "Eligius miners aware of prayers in block headers?" from on bitcointalk.org by user "Graet" who quotes prior discussion from a Bitcoin IRC channel:<luke-jr> cosurgi: by design, it contains "random" data-- I've just been setting some of that "random" data to prayers<Graet> mm interesting luke-jr i understand you are strong in your faith but you dont think putting prayers in might alienate some ppl - after all btc is multidenominational<luke-jr> Graet: Catholics do not believe in freedom of religion.<Graet> and you make your non catholic miners aware of this?
- 2011-11-02 bitcointalk.org/index.php?topic=52979.0 "Mysterious transaction spotted in blockchain!"
Transactions such as tx fe37c7eee73be5fda91068dbe0eb74a68495a3fc7185712b8417032db7fc9c5e (2015-01-15) starting withare Base64 encoded. Running them through we might as well give up. That string appears 26 times in our data currently, between 6c091e6152b83ec0df8d0d87c7c5f3da72a3328ed3a5d91768ba0ab899c16b9d (2014-09-28) and 84189c82995db355e92e37f8cfe8a9274e9a5d157f1f1658067672e707469a09 (2019-07-06)
U2FsdGVkX1/4iSjLxQ5epo8eRSCOQLGgAsn1CucGii27k8ZyC7Jz6wxhYcevVmxi
6Q4ZFN04WDN0UhKqYardgQf26oeBMURupduDd0ZozxlgMrBkFOCaARqU7RABVWDO
/ruPUcOY0VC8p4lrMNqSdqvN7y6OWwOSH3c0duumZfFNZs9+BbtKCxtaqR5+RkUIbase64 -d leads to starting output bytes Salted__ which as mentioned at security.stackexchange.com/questions/124312/decrypting-binary-code-from-a-base64-string is OpenSSL encrypted data. So hwerever we see the start:U2FsdGVkX1/The following via cryptograffiti.info get marked by
file as "openssl enc'd data with salted password, Base64 encoded":- ad3d8a0a5d57114b1780341cb5104284f029bb01b1b3558f7c7b9ce51eb67e18
- 1cd0c631f444d664601468f644b70e0166019a54d8678de51310139b6c8b2bd7
- ccc3fb2c9cb1c640b76645a8658693066fd63433ab17c318691ad5bd62601c0e
- e6eb0cb8268a9b3d012d2957b32d4b28ccc3317593f54f4bfe4b387326588bd2
- c40e322b198b715accc4a67fad244ed131b8cef0785070e06d10d56c4ab389f2
- 37a261ac6dbf59e3c9673a22028bcdbdd08926a9d32134ab8fba0897f6dcd196
- f1aa516fe00ec2156f16fcb9da422f6cbcd141e8e58c895d8bc37b4ad2fd714e
- 7faf29c7dd7d9cc6d099c262f7ec7edd7fc768276482ad66ceefdd814f1d38ab
- 69cac244051661cc0b8b08905af5ab312a1282b68c932e5d1e3c46ad47ff0f7a
- 1773c39f844951b7169dc34aa0c72aa7b43cae6a103ed1223527ef0f4deec2a9
- b1d4bf3fc46e63c995ad4299f3576340077bc810dfa5c502d1c068460d54bc98
- a52625837741902e1dd24de3dbd3b948d6e0907ad3fc957c13cdf53fa2c3b9ac
- 4ca742813eaccef009e24e92150dda06540c2ac81782f1569b1ebb3179a413d2
- 6c3bab5fc6e6352c62a16ab0f47394845aa41a2c0b25e1a1073a4aeac150e03d
- 20b8feef3d293a0dd79e3c169fceb1217465502a523acbab903a7eb0cd183709
- b7863215b99567bc9e71155b13f3c5f26d15eac52493ee2e834129460ffd2aec
- 2c8961a64bb11d5855790085f51007273467f7ef862137215c9f1d958dcb6c57
- bed542957bdd8f644a4fcd671a8c66a5cc5d6168f9fa60d37177703e77558eee
- 3e45af9d828754d5a38c86636a070610f6e828482718c4a597d272d41a3e31fa
- a13af4817e85cacce3cfb445001e2fb2f56cdc30f78348fd2580bf8f4c84dc55
- 87a10f6bc65a08067b2544e46be00d4af62c0cfed3ae0b165d5eedaff09d81da
- ef55826befabbe9dcd44d87fc385d600dd4c4cba3346cde53d8c591960e9b4dc
- 5d30f63131dcf2b4d001b4ab530e18cc6ff8ffd16cade055ff4587a59b84e420
- 8a75514829b6e30b9fea434eef77b1589ff3f4bdfc0056bd087efbfb8314eb59
- e2be1062c9d43cc6ed43de6f7a40c728d2d92ed0325abde24ff3300cf3ae136a
- 8fe5c2679237e36c74fda04bb083f732c4afdd06af81121b1d7b4d5bd677135f
- 7f099f094d8d51105d8655253d45ebddf1c88b9e138c302a65d2878a237e620c
- 0fc4b3a305e2a7faa2e7d9c2f23d23d626e9e75f1f2a37133f283334b314645b
- 933b321e7b7144ed5e4e1750f944be9ed10293633d9b288bf05febdeb9dc40a3
- 6215486bc024dea7991b142e50e111c4063e1db4a867514612b8e794b8ef5635
- fc0613e11269962d97373b10e310f451fb76c7bb477ba1afb45773c44851e9ed
- ab51d2c037b4625394c68706da83c26bad751018d2a3e377a51988bd8ee18647
- 7ca9b337172f4feff67a0ecbfbd76798265e08c6ebe989a319883c695d756247
- 0f0b477e456dcf286d7262497bcd5b3b6a3ce89f81761c2f59ff702539ab6183
- a320152fd59426c8853dd781db9d682f89755953b39a653f9e9c9628a5fce7fb
- e96221da774fb52d24dda1b83b14c99085eb4befac64691722c56eb750562d68
- a7a5ca68dd340dd42bd5c91e0febe68e5fd2fb993da2992661183eaafe8ad89e
- 64e9d95e2333cfd155506199c8d926649e63a98dbc83c1221b8dd1580937b942
blockchain.news/news/mysterious-bitcoin-inscriptions-a-puzzle-in-raw-binary-data mentions a huge 9 MB Ordinal ruleset inscription that no-one managed to decode, and so people suspect is encrypted data. Seems to be split across transactions, starting at fed7de7fb75a3fe3c1acbbd8e19a4c540fb368474c8834e4ddb1d5bab764a767
The default run variant, if you don't pass any options, just has the minimal growth conditions set. What this means can be seen at condition.
Notably, this implies a growth medium that includes glucose and salt. It also includes oxygen, which is not strictly required, but greatly benefits cell growth, and is of course easier to have than not have as it is part of the atmosphere!
But the medium does not include amino acids, which the bacteria will have to produce by itself.
Got it working as mentioned at: github.com/cirosantilli/feathers-chat/tree/sequelize-pg
Bibliography:
There's also a
heroku branch at: github.com/feathersjs/feathers-chat/tree/heroku, but it also seems to use NeDB? So you can have a filesystem in Heroku? Doesn't seem so: stackoverflow.com/questions/42775418/heroku-local-persistent-storageThis is a good company, first they truly helped reduce international transfer fees. They they continued to morph into a decent challenger bank.
Their Wise Interest account was amazing as of late 2023: wise.com/gb/interest/
Instant access with representative national interests and 0.29% fees.
Brick and mortar banks were way way behind in that regard!
E.g. October 2023, Wise was doing 4.87% interest after fees, while Barclay's best option was 1.16% above 5k pounds on the Rainy Day Saver (5% below). Ridiculous!
Update: On November 2023 unfortunately they more than doubled their fees from 0.19% to 0.46%:but it still was a good option to keep cash in.
These are good free newbie GUI options:
sudo apt install meld
git mergetool --tool meld
sudo apt install kdiff3
git mergetool --tool kdiff3
Let's make a more interesting conflict:
git-tips-2.sh
#!/usr/bin/env bash
set -eux
add() (
rm -f f
for i in `seq 10`; do
printf "before $i\n\n" >> f
done
printf "conflict 1 $1\n\n" >> f
for i in `seq 10`; do
printf "middle $i\n\n" >> f
done
printf "conflict 2 $2\n\n" >> f
for i in `seq 10`; do
printf "after $i\n\n" >> f
done
git add f
)
rm -rf git-tips-2
mkdir git-tips-2
cd git-tips-2
git init
for i in 1 2 3; do
add $i $i
git commit -m $i
done
add 3 4
git commit -m 4
add 5 4
git commit -m 5
git checkout HEAD~2
git checkout -b my-feature
add 3 6
git commit -m 6
add 7 6
git commit -m 7Before:
5 master
|
4 7 my-feature HEAD
| |
3 6
|/
2
|
1Action:
git rebaseAfter:Ready to push with linear history!
7 my-feature HEAD
|
6
|
5 master
|
4
|
3
|
2
|
1By default, NASM places a
.symtab on the executable as well.This is only used for debugging. Without the symbols, we are completely blind, and must reverse engineer everything.
You can strip it with
objcopy, and the executable will still run. Such executables are called "stripped executables". There are unlisted articles, also show them or only show them.