Children: Bioinformatics
A heat map is a data visualization technique that uses color to represent the magnitude of values in a dataset. The colors typically range from cooler shades (like blue or green) for lower values to warmer shades (like yellow or red) for higher values. Heat maps are particularly useful for identifying patterns, correlations, and anomalies within data.
Hierarchical Editing Language for Macromolecules (HELIX) is a specialized language designed for representing and manipulating macromolecular structures, often used in computational biology and bioinformatics. The primary purpose of HELIX is to provide a means to describe complex biological macromolecules, such as proteins and nucleic acids, in a structured and hierarchical format.
HomoloGene is a database developed by the National Center for Biotechnology Information (NCBI) that is designed to facilitate the identification of homologous genes across different species. Homologous genes are those that share a common ancestor and can be categorized into two main types: orthologs and paralogs. - **Orthologs** are genes in different species that evolved from a common ancestral gene and typically retain similar functions.
Homology modeling, also known as comparative modeling, is a computational technique used in structural biology to predict the three-dimensional structure of a protein based on its sequence similarity to one or more proteins whose structures are known (the template proteins). The underlying assumption of homology modeling is that similar sequences often indicate similar structures, due to the constraints imposed by evolutionary relationships.
Horizontal correlation typically refers to the relationship between entities or variables that are similar or comparable across a certain dimension. In various fields, the term can take on specific meanings, but it generally signifies how changes in one entity are related to changes in another entity on the same level or scale.
HubMed is a specialized search engine designed for accessing and searching the medical literature, primarily focused on biomedical and life sciences. It was created to provide more refined search capabilities compared to general search engines and even some traditional databases. Users can search for articles, abstracts, and other resources from a variety of medical journals and publications. The platform allows users to customize their searches using features like filters, tags, and personalized collections, making it easier to find relevant research content quickly.
The Human Epigenome Project (HEP) is an initiative aimed at mapping and understanding the epigenome, which consists of chemical modifications to DNA and histone proteins that regulate gene expression without altering the underlying DNA sequence. These modifications can affect how genes are turned on or off, influencing various biological processes, development, and disease susceptibility.
The Human Genome Project (HGP) was a landmark scientific endeavor that aimed to map and understand all the genes of the human species. It was officially launched in 1990 and completed in April 2003, although the analysis of the data continued for some time afterward. The primary goals of the HGP included: 1. **Sequencing the Human Genome**: Determining the complete sequence of the human DNA, which consists of approximately 3 billion base pairs.
The Human Microbiome Project (HMP) is a major research initiative launched by the National Institutes of Health (NIH) in the United States in 2007. Its primary aim is to characterize the microbial communities that inhabit the human body, collectively termed the human microbiome, and to understand their roles in human health and disease.
Human Proteinpedia is an online database that serves as a comprehensive repository of human protein information. The platform aggregates data related to the human proteome, focusing on various aspects such as protein sequences, structures, functions, and expression profiles. It is designed to facilitate research in areas like biology, medicine, and biotechnology by providing easy access to a wealth of information about proteins.
Hybrid genome assembly is a technique that combines multiple sequencing technologies to generate a more accurate and complete representation of an organism's genome. This approach typically merges the high accuracy of short-read sequencing (like Illumina) with the longer reads produced by technologies such as Pacific Biosciences (PacBio) or Oxford Nanopore. Here are the main components and benefits of hybrid genome assembly: ### Components: 1. **Short-Read Sequencing**: - High-throughput and cost-effective.
Hypothetical proteins are sequences of amino acids predicted to be produced by a particular gene, but for which no experimental evidence of their function, structure, or interaction has yet been established. These proteins are often identified through genome sequencing and bioinformatics analyses, where computational methods suggest that the gene could encode a protein based on its DNA sequence.
IMGT, or the Immunogenetics Information System, is a global reference database and information system dedicated to immunogenetics and bioinformatics. It is primarily focused on the study of immunoglobulins (antibodies), T-cell receptors, and major histocompatibility complex (MHC) molecules, among other components of the immune system.
The ISCB Africa ASBCB Conference on Bioinformatics is a regional conference organized by the International Society for Computational Biology (ISCB) in collaboration with the African Society for Bioinformatics and Computational Biology (ASBCB). This conference aims to bring together researchers, practitioners, and students in the fields of bioinformatics, computational biology, and related areas, particularly focusing on the African context.
The ISCB Fellow is an honor conferred by the International Society for Computational Biology (ISCB) to recognize individuals who have made significant contributions to the field of computational biology. This distinction is meant to acknowledge not only outstanding research contributions but also service to the community, leadership, and mentorship within the field. ISCB Fellows are typically elected through a rigorous selection process, and they are recognized during ISCB events, such as the annual ISMB (Intelligent Systems for Molecular Biology) conference.
The ISCB Innovator Award is presented by the International Society for Computational Biology (ISCB) to recognize individuals or teams who have made significant contributions to the field of computational biology through innovative research, methodologies, or applications. The award aims to honor groundbreaking work that has advanced the field and provided new insights into the biological sciences.
The ISCB Senior Scientist Award is an accolade presented by the International Society for Computational Biology (ISCB) to recognize outstanding contributions to the field of computational biology and bioinformatics. This prestigious award honors scientists who have made significant advancements through their research, innovation, and leadership in the field. Typically, nominees for this award are established researchers whose work has had a substantial impact on the discipline and has helped to advance the understanding of biological problems through computational approaches.
ITools Resourceome is a web-based bioinformatics tool designed for the visualization and analysis of biological data, particularly in the context of genomics and proteomics. It provides users with a platform to explore various resources related to gene expression, protein interaction, and other biological data sets. The tool aims to integrate diverse biological information and facilitate research by offering features such as data mining, graphical representation, and analysis options.
Identifiers.org is a platform that provides persistent identifiers for various types of resources in the life sciences and other fields. It serves as a registry for a range of identifier schemes, helping to facilitate data sharing and interoperability among different databases and systems. The service supports a variety of identifiers, including but not limited to: - Biological resources (e.g., genes, proteins, species) - Datasets - Publications By offering a consistent and reliable way to reference these resources, Identifiers.