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Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis by Jeff H. Tsai and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Identification of the tumour transition states occurring during EMT by Ievgenia Pastushenko and others by
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Ievgenia Pastushenko and coauthors. 2018. Nature 556, 463–468.
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance by Kari R. Fischer and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Kari R. Fischer and coauthors. 2015. Nature 527, 472–476.
Tumor-infiltrating lymphocyte therapy or ipilimumab in advanced melanoma by Maartje W. Rohaan and others by
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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells by Sanjeev Mariathasan and others by
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Sanjeev Mariathasan and coauthors. 2018. Nature 554, 544–548.
Mutations associated with acquired resistance to PD-1 blockade in melanoma by Jesse M. Zaretsky and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2 by Richard A. Morgan and others by
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Richard A. Morgan and coauthors. 2010. Molecular Therapy 18, 843–851.
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes by F. William Studier and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: pubmed.ncbi.nlm.nih.gov/3537305/
Relevant passages: Abstract and pp. 113–130, inducible selective expression.
Molecular structure of a left-handed double helical DNA fragment at atomic resolution by A. H.-J. Wang and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: doi.org/10.1038/282680a0
Relevant passages: pp. 680–686, alternating CG duplex and left-handed structure.
Sequence-specific recognition of double helical nucleic acids by proteins by Nadrian C. Seeman and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: williams.chemistry.gatech.edu/course_Information/nucleic_acid_biochem/articles/rich_pnas_1976.pdf
Relevant passages: pp. 804–808, accessibility of base-edge recognition patterns.
A mediator required for activation of RNA polymerase II transcription in vitro by Peter M. Flanagan and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: pubmed.ncbi.nlm.nih.gov/2011193/
Relevant passages: Abstract and pp. 436–438, biochemical requirement for mediator activity.
Structural basis of transcription activation: the CAP-alpha CTD-DNA complex by Brian Benoff and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: pubmed.ncbi.nlm.nih.gov/12202833/
Relevant passages: pp. 1562–1566, CAP–alpha-domain contact and transcription-activation complex.
Thiamine derivatives bind messenger RNAs directly to regulate bacterial gene expression by Wade Winkler and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: pubmed.ncbi.nlm.nih.gov/12410317/
FourU: a novel type of RNA thermometer in Salmonella by Torsten Waldminghaus and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: pubmed.ncbi.nlm.nih.gov/17630972/
Characterization of Proteins by Size-Exclusion Chromatography Coupled to Multi-Angle Light Scattering (SEC-MALS) by Daniel Some and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: pubmed.ncbi.nlm.nih.gov/31282880/
Relevant passages: Abstract and protocol, hydrodynamic SEC calibration versus concentration-coupled light scattering.
Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide by Keqin Chen and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: pmc.ncbi.nlm.nih.gov/articles/PMC46772/
Relevant passages: pp. 5618–5622, sequential mutagenesis, screening and characterization in organic solvent.
Kemp elimination catalysts by computational enzyme design by Daniela Röthlisberger and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: www.nature.com/articles/nature06879
Relevant passages: pp. 190–195, designed catalytic sites and experimental improvement.
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression by A. De Vos and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation by Benjamin Glaser and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Primary source: www.nejm.org/doi/full/10.1056/NEJM199801223380404
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





