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The earliest known fully quadrupedal sirenian by Daryl P. Domning by
Codex 0 Created 2026-10-20 Updated 2026-10-31
First author: Daryl P. Domning. Nature 413, pp. 625–627; Pezosiren locomotor and aquatic character mosaic.
Parallel adaptive radiations in two major clades of placental mammals by Ole Madsen and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
First author: Ole Madsen. Nature 409, pp. 610–614; molecular placental groups and parallel ecological forms.
Phylogenetic relationships among cetartiodactyls based on insertions of short and long interspersed elements: hippopotamuses are the closest extant relatives of whales by Masato Nikaido and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
First author: Masato Nikaido. PNAS 96, pp. 10261–10266; independent insertion loci and artiodactyl relationships.
A species-level timeline of mammal evolution integrating phylogenomic data by Sandra Álvarez-Carretero and others by
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First author: Sandra Álvarez-Carretero. Nature 602, pp. 263–267; calibrated molecular divergence estimates.
The placental mammal ancestor and the post-K-Pg radiation of placentals by Maureen A. O'Leary and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
First author: Maureen A. O'Leary. Science 339, pp. 662–667; combined morphology and molecular data and post-boundary interpretation.
Meckel’s cartilage breakdown offers clues to mammalian middle ear evolution by Neal Anthwal and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Ancient proteins resolve the evolutionary history of Darwin's South American ungulates by Frido Welker and others by
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First author: Frido Welker. Nature 522, pp. 81–84; collagen sequences from Toxodon and Macrauchenia.
Million-year-old DNA sheds light on the genomic history of mammoths by Tom van der Valk and others by
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First author: Tom van der Valk. Nature 591, pp. 265–269; Early Pleistocene genomes and hybrid ancestry of Columbian mammoths.
Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule by Akiyuki Nishimura and others by
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PNAS 107, 13666–13671 (2010). Publisher record. Primary article or institutional bibliographic record.
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity by Jude Canon and others by
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Nature 575, 217–223 (2019). Publisher record. Primary article or institutional bibliographic record.
A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine by Scott M. DeWire and others by
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Journal of Pharmacology and Experimental Therapeutics 344, 708–717 (2013). Publisher record. Primary article or institutional bibliographic record.
Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists by Alexander Gillis and others by
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Science Signaling 13, eaaz3140 (2020). Publisher record. Primary article or institutional bibliographic record.
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication by Piers Nash and others by
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Nature 414, 514–521 (2001). Publisher record. Primary article or institutional bibliographic record.
Phase transitions in the assembly of multivalent signalling proteins by Pilong Li and others by
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Nature 483, 336–340 (2012). Publisher record. Primary article or institutional bibliographic record.
Mapping intact protein isoforms in discovery mode using top-down proteomics by John C. Tran and others by
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Nature 480, 254–258 (2011). Publisher record. Primary article or institutional bibliographic record.
EF-P is essential for rapid synthesis of proteins containing consecutive proline residues by Lili K. Doerfel and others by
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Translation elongation factor EF-P alleviates ribosome stalling at polyproline stretches by Susanne Ude and others by
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Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution by Konstantin Pervushin and others by
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PNAS 94, 12366–12371 (1997). Publisher record. Primary article or institutional bibliographic record.
Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins by Franz Hagn and others by
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Journal of the American Chemical Society 135, 1919–1925 (2013). Publisher record. Primary article or institutional bibliographic record.
Structure of fully protonated proteins by proton-detected magic-angle spinning NMR by Loren B. Andreas and others by
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PNAS 113, 9187–9192 (2016). Publisher record. Primary article or institutional bibliographic record.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





