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Order-of-magnitude enhancement in photocurrent generation of Synechocystis sp. PCC 6803 by outer membrane deprivation by Shoko Kusama and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Outer-membrane perturbation, ferricyanide reduction and supernatant substitution tests identify a barrier to cyanobacterial electron export.
Coupled, Circumferential Motions of the Cell Wall Synthesis Machinery and MreB Filaments in B. subtilis by Ethan C. Garner and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Live fluorescence measurements link circumferential MreB-associated movement to peptidoglycan synthesis.
Protection against extreme turgor by MscS and MscL by N. Levina and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Loss-of-function and osmotic-downshock experiments demonstrate emergency channel protection from lysis.
Pyocyanin Alters Redox Homeostasis and Carbon Flux through Central Metabolic Pathways in Pseudomonas aeruginosa PA14 by Alexa Price-Whelan and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
The PqsE-RhlR Interaction Regulates RhlR DNA Binding to Control Virulence Factor Production in Pseudomonas aeruginosa by Kayla A. Simanek and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Functional Analysis of Genes for Biosynthesis of Pyocyanin and Phenazine-1-Carboxamide from Pseudomonas aeruginosa PAO1 by Dmitri V. Mavrodi and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Bending Gradients: How the Intestinal Stem Cell Gets Its Home by Amy E. Shyer and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Amy E. Shyer and collaborators. Cell 161, pp. 569–580; tissue geometry, epithelial Shh concentration and mesenchymal BMP induction.
Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin by Amy E. Shyer and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Amy E. Shyer and collaborators. Science 357, pp. 811–815; dermal aggregation, contractility and epidermal β-catenin activation.
The Strength of Mechanical Forces Determines the Differentiation of Alveolar Epithelial Cells by Jiao Li and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Jiao Li and collaborators. Developmental Cell 44, pp. 297–312.e5; mechanical-force perturbation, cell shape and alveolar differentiation.
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable by Hua Tian and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Hua Tian and collaborators. Nature 478, pp. 255–259; Lgr5-DTR depletion, ongoing epithelial maintenance and Bmi1-lineage contributions.
Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration by Ciara Metcalfe and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells by Kazutaka Murata and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Kazutaka Murata and collaborators. Cell stem cell 26, pp. 377–390.e6; absorptive and secretory precursor dedifferentiation and Ascl2 requirements.
A single type of progenitor cell maintains normal epidermis by Elizabeth Clayton and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Elizabeth Clayton and collaborators. Nature 446, pp. 185–189; quantitative sparse clonal fate mapping and population self-renewal.
A single progenitor population switches behavior to maintain and repair esophageal epithelium by David P. Doupé and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By David P. Doupé and collaborators. Science 337, pp. 1091–1093; label retention, stochastic lineage dynamics and reversible wound responses.
Distinct contribution of stem and progenitor cells to epidermal maintenance by Guilhem Mascré and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Guilhem Mascré and collaborators. Nature 489, pp. 257–262; marker-selected populations, proliferation kinetics and hierarchy.
Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation by Kailin R. Mesa and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Kailin R. Mesa and collaborators. Cell stem cell 23, pp. 677–686.e4; intravital tracking, local cell loss and compensatory division.
Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties by Giacomo Donati and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Giacomo Donati and collaborators. Nature Cell Biology 19, pp. 603–613; pre-injury lineage labelling, live-cell imaging and sebaceous-duct cell plasticity.
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities by Brian D. Harfe and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Brian D. Harfe and collaborators. Cell 118, pp. 517–528; Shh lineage history, expansion and duration-dependent digit patterning.
Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development by Fabienne Lescroart and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Fabienne Lescroart and collaborators. Nature Cell Biology 16, pp. 829–840; timed Mesp1 clonal labelling and regional lineage segregation.
Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells by Shuichi Ueno and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
By Shuichi Ueno and collaborators. PNAS 104, pp. 9685–9690; stage-specific Wnt manipulation and cardiac specification.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





