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Nodal signalling in the epiblast patterns the early mouse embryo by Jane Brennan and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Jane Brennan.
Nature 411, pp. 965–969. Genetic analysis of epiblast-to-extraembryonic signalling and axis organization.
Cell fate decisions within the mouse organizer are governed by graded Nodal signals by Stéphane D. Vincent and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Stéphane D. Vincent.
genes & Development 17, pp. 1646–1662. Genetic reduction of Nodal/SMAD2 pathway activity tests organizer and definitive endoderm contributions.
FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak by Brian Ciruna and Janet Rossant by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Developmental cell 1, pp. 37–49. FGFR1 mutants, Snail/E-cadherin and mesoderm markers distinguish fate and epithelial-to-mesenchymal transition.
A gradient of bicoid protein in Drosophila embryos by Wolfgang Driever and Christiane Nüsslein-Volhard by
Codex 0 Created 2026-10-20 Updated 2026-10-31
The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner by Wolfgang Driever and Christiane Nüsslein-Volhard by
Codex 0 Created 2026-10-20 Updated 2026-10-31
The Drosophila posterior-group gene nanos functions by repressing hunchback activity by Vivian Irish and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos by Robin P. Wharton and Gary Struhl by
Codex 0 Created 2026-10-20 Updated 2026-10-31
cell 67, pp. 955–967. Reporter and response-element tests establish sequence-dependent translational regulation.
RNA recognition and translational regulation by a homeodomain protein by Josh Dubnau and Gary Struhl by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Dishevelled controls cell polarity during Xenopus gastrulation by John B. Wallingford and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include John B. Wallingford.
Nature 405, pp. 81–85. Time-lapse confocal imaging separates polarity and convergent-extension defects from loss of cell fate.
Collective mesendoderm migration relies on an intrinsic directionality signal transmitted through cell contacts by Julien G. Dumortier and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Julien G. Dumortier.
Forces driving epithelial spreading in zebrafish gastrulation by Martin Behrndt and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Martin Behrndt.
Archetypal organization of the amphioxus Hox gene cluster by Jordi Garcia-Fernàndez and Peter W. H. Holland by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Nature 370, pp. 563–566. Genomic cluster comparison informs ancestral chordate Hox organization; modern amphioxus is not an ancestral individual.
Developmental Roles of Pufferfish Hox Clusters and Genome Evolution in Ray-Fin Fish by Angel Amores and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Angel Amores.
Hox cluster disintegration with persistent anteroposterior order of expression in Oikopleura dioica by Hee-Chan Seo and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Hee-Chan Seo.
Nature 431, pp. 67–71. genome organization and in situ expression demonstrate dispersion with residual positional ordering.
Uncoupling time and space in the collinear regulation of Hox genes by Patrick Tschopp and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Patrick Tschopp.
A switch between topological domains underlies HoxD genes collinearity in mouse limbs by Guillaume Andrey and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Guillaume Andrey.
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans by Andrew Fire and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Andrew Fire.
Nature 391, pp. 806–811. Double-stranded versus single-stranded RNA injection controls establish potent sequence-specific interference.
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 by Rosalind C. Lee and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Rosalind C. Lee.
Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila by Julius Brennecke and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Julius Brennecke.
cell 128, pp. 1089–1103. Piwi-family immunoprecipitation and small-RNA sequencing identify clusters and complementary piRNA populations.
An epigenetic role for maternally inherited piRNAs in transposon silencing by Julius Brennecke and others by
Codex 0 Created 2026-10-20 Updated 2026-10-31
Authors include Julius Brennecke.
Science 322, pp. 1387–1392. Reciprocal crosses link maternal piRNAs to transposon control and hybrid dysgenesis.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





