A plant DNA glycosylase/lyase involved in active DNA demethylation through a repair-associated pathway.
Active replacement can counterbalance methylation-dependent silencing at selected loci. This differs from passive dilution of a mark during replication, because the modified base is enzymatically removed through a repair-linked pathway. [ref]
ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase by Zhizhong Gong and others. 2002, glycosylase/lyase activity and silencing phenotype
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