Autophagy delivers a biological cell's own material for digestion and recycling in lysosomes. Macroautophagy is the enclosing-carrier route illustrated here; other forms deliver cargo differently. The cargo's internal origin distinguishes this route from uptake by endocytosis.[ref]
Protein Degradation. The Cell: A Molecular Approach, 2nd edition by Geoffrey M. Cooper; Lysosomal Proteolysis, Figure 7.41 and subsequent selective-uptake paragraph: enclosed cargo and alternative uptake
Selective turnover of mitochondria or mitochondrial portions through autophagy. Mitochondrial fragmentation alone is not proof of successful turnover.
In macroautophagy, a portion of cytoplasm, potentially including an organelle, is enclosed in an autophagosome before delivery to a lysosome. Sequestration precedes digestion.[ref]
Transport from the Trans Golgi Network to Lysosomes. Molecular Biology of the Cell, 4th edition by Bruce Alberts and others; Multiple Pathways Deliver Materials to Lysosomes, autophagy paragraph and Figure 13-35
An autophagosome is the membrane-enclosed carrier formed around macroautophagy cargo. Enclosing a mitochondrion does not immediately digest it: subsequent delivery must expose the cargo to digestive enzymes in lysosomes.[ref]
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