Colin Dingwall coauthored experiments identifying a protein domain that directs nucleoplasmin into the cell nucleus. Comparing fragments and injection locations separates nuclear import from simple retention after entry.
A domain can provide localization information without being the whole protein. Testing both cytoplasmic and nuclear placement helps distinguish a targeting signal from a feature that merely prevents export.[ref]
A polypeptide domain that specifies migration of nucleoplasmin into the nucleus by Colin Dingwall and others. Figures 2–3, 5, and 7: import and retention comparisons
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