Signal transduction initiated by Wnt-family ligands. Distinct pathway branches regulate gene expression, cell polarity and cell behaviour; their effects depend on developmental context.
A signalling protein involved in canonical Wnt and planar cell polarity pathways. Perturbations can disrupt oriented cell movement without abolishing the associated cell fate.
A signalling system that produces different transcriptional states in sister cells. In the Caenorhabditis elegans EMS division, nuclear POP-1 and SYS-1 levels establish different coactivator-to-transcription-factor ratios.
A member of a secreted signaling-protein family acting through Wnt signalling pathways. Adding ligand need not produce a measurable reporter change if the responding machinery or assay range is unsuitable.
The Wnt ligand participating in the P2-to-EMS interaction during early Caenorhabditis elegans development.
A signal from the neighbouring P2 cell helps distinguish the developmental programmes of the EMS daughters. Combining wild-type and mutant blastomeres tests whether a defect lies in signal production or in the responding cell’s competence. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 21, Caenorhabditis elegans development and cell-cell interactions
A Wnt-family ligand with a role in dorsal limb patterning through induction of a dorsal transcriptional programme in competent mesenchyme.
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