GUK1

GUK1 is the symbol for a gene encoding guanylate kinase. In the human annotation, GUK1 is the protein-coding gene named guanylate kinase 1, identified by NCBI GeneID2987. The gene is a DNA locus; the encoded enzyme catalyses chemistry after its expression.^[ref]

The enzyme transfers a phosphoryl group between ATP and guanosine monophosphate, giving ADP and guanosine diphosphate. A compact biochemical notation isPhosphorus bookkeeping gives $3+1=2+2$. The equation describes the protein's activity, not a chemical reaction performed directly by the DNA.

A 1992 study cloned and characterized the yeast gene for guanylate kinase, connecting an inherited sequence with a measured enzyme activity.^[ref] The organism must be stated when identifying a gene: the same functional symbol in yeast and humans does not mean that both organisms carry one identical DNA sequence. Likewise, a change in transcript abundance is not by itself a measurement of catalytic rate.