An inherited disorder is a disorder associated with a genetic variant transmitted from a parent. Dominant, recessive and sex-linked patterns describe different relationships between inheritance and expression. Inherited risk need not imply certainty of disease because penetrance, other genes and environment can affect the outcome. A genetic condition caused by a new mutation in an individual is genetic without necessarily having been inherited from a parent. [ref]
An inherited predisposition to several cancers associated with defective DNA mismatch repair, commonly through inherited variants in mismatch-repair genes.

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