M. D. Smigel helped investigate the purified regulatory component of adenylyl cyclase. Connecting its guanine-nucleotide-dependent properties with restored hormone stimulation showed how biochemical separation and reconstitution can identify a signaling component.[ref]
The regulatory component of adenylate cyclase. Purification and properties by P. C. Sternweis and others. 1981, abstract, properties 2–4: purified component and functional reconstitution
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