A Michael addition makes a bond at the beta carbon of a conjugated electrophile through conjugate addition. An enamine can supply a carbon nucleophile; subsequent hydrolysis restores its original carbonyl group.
Conjugate addition of a thiol-derived sulfur nucleophile to an activated alkene. The sulfur substituent is installed at the beta carbon of an enone, not at its carbonyl carbon.
A sequence in which one conjugate addition generates or exposes a nucleophile for another conjugate addition. Atom mapping distinguishes successive bond-forming steps from a concerted cycloaddition.
Conjugate addition involving a nitroalkene electrophile or a nitronate nucleophile. Identifying which partner supplies the carbon nucleophile is essential for following a tandem reaction.
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