A negative control is a comparison expected to lack the response attributed to the tested cause. In a generic analytical measurement, a blank without the target substance reveals background signal or contamination introduced by reagents and handling. A vehicle control can isolate effects of the carrier used to deliver an intervention. A clean negative control supports interpretation but cannot prove that every unwanted influence is absent; the control must share the relevant conditions with the test samples.[ref]
A comparison receiving the solvent or delivery formulation without the active compound. It separates compound-associated effects from effects of the formulation.

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