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Two charged-current beta vertices can be connected by a virtual Majorana neutrino. With light exchanged masses relative to nuclear momentum scales, the chirality connection makes the amplitude proportional to ${\sum }_i{U}_{ei}^2{m}_i$, not an incoherent mass average. Squaring introduces the effective Majorana mass, nuclear matrix elements and phase space. Other lepton-number-violating operators can also mediate the same final state, so translating a rate into a mass requires the stated mechanism.

A Majorana neutrino is its own antiparticle, with a mass term that can violate lepton number by two units. It is not thereby a state of both readily observable helicities with equal weak rates: charged-current vertices still select chirality. In light-neutrino exchange, the needed helicity connection between two beta vertices supplies a neutrino-mass factor.

Ordinary two-neutrino double beta decay is $(A,Z)\to (A,Z+2)+2e^{-}+2{\bar{\nu }}_e$ and conserves lepton number. It can occur when the direct single-beta route is energetically forbidden or highly suppressed but the double change is allowed. neutrinoless double beta decay, $(A,Z)\to (A,Z+2)+2e^{-}$, violates lepton number by two. For the conventional light-Majorana exchange in neutrinoless double beta decay mechanism,Here $U$ is the lepton mixing matrix, $G_{0\nu }$ the phase-space factor in this convention and ${\mathcal{M}}_{0\nu }$ a nuclear matrix element. Complex phases can cancel contributions to the effective Majorana mass; oscillation mass differences alone do not fix it. Other lepton-number-violating mechanisms can also cause the process, so a rate is not a model-independent measurement of $m_{\beta \beta }$.

The experimental signature is a peak in the summed electron energy at the nuclear Q-value, apart from small recoil and energy losses. Two-neutrino decay instead gives a continuous sum-energy radiation spectrum because neutrinos carry away variable energy. Isotope enrichment, large exposure, good energy resolution and radiopure shielding improve sensitivity; gamma backgrounds, radon, surface events and the two-neutrino tail require calibration and sideband controls. Coincidence or track information can test whether the topology is compatible with two electrons. A later concrete example is GERDA's 2013 germanium-76 source-detector search, which used pulse-shape discrimination and background controls rather than identifying any isolated energy deposit as a decay.^[ref]

A low-momentum dark-matter–nucleon elastic cross section and a high-energy collider pair-production cross section are different observables. Crossing of amplitudes does not equate their numerical values. Mediator masses, couplings, nuclear matrix elements, parton distributions and kinematics enter the relation. Collider sensitivity further requires a trigger, visible recoil, acceptance and background treatment. Multiplying a direct-detection cross section by collider luminosity is therefore only a hypothetical dimensional estimate unless a production model justifies the substitution.