On these eight runs, and . The two independent defining words therefore give the full signed defining relationMultiplying each desired factorial contrast by its four words gives all aliases. In the following equalities a minus sign means opposite contrast columns:Thus two main effects, and , are inseparable even when every unwanted interaction vanishes. In addition, the important interaction aliases with the main effect . Design (a) is unsuitable. The seven-column design matrix for the intercept, the five main effects and has rank five, confirming the two independent estimability failures.
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