For a regular iid model with a fixed-dimensional interior parameter , identifiability, sufficient differentiability and moment domination, and nonsingular per-observation Fisher information , a consistent maximum-likelihood estimator solves the score equation. Expanding it gives
where . The score has mean zero and covariance under the regularity assumptions. This proves the usual large-sample information bound and asymptotic efficiency within regular parametric inference. The observed curvature and the empirical score covariance consistently estimate when the model is correctly specified.
For smooth constraints with full-row-rank derivative , the Wald test uses
The likelihood-ratio test and score test, evaluated using the constrained fit and nuisance-adjusted efficient information, have the same first-order chi-square law. A quadratic local likelihood expansion explains their asymptotic equivalence. Profile likelihood supplies inference about a parameter of interest with fitted nuisance parameters, and the corresponding chi-square cutoffs give approximate confidence regions.
These conclusions depend on the stated regularity: parameters at a boundary, nonidentifiability, singular information, changing dimension, or parameter-dependent support can give different rates and limits. Under misspecification, the fitted parameter generally approaches a pseudo-true value and its variance is a sandwich covariance matrix, not simply inverse Fisher information.

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