Use the normal linear model , with fixed full-column-rank design matrix , independent errors , and . Its log-likelihood is
For fixed , differentiating with respect to gives . Since is positive-definite, the unique least-squares estimate is
Let . The variance score equation is , giving
This is the maximum-likelihood estimator, whereas the residual standard error reported by linear-regression software is . The latter uses the unbiased residual estimate of Gaussian noise variance. These formulas assume and positive RSS; exact interpolation gives a variance-boundary degeneracy rather than an interior maximum.

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