The event separation is timelike precisely when
A simultaneous pair in an inertial frame would instead have . Since a Lorentz transformation preserves this interval, no such simultaneous frame exists. A timelike pair can be brought to the same spatial position: the required velocity is , whose magnitude is less than .
The separate condition says that the two event-position four-vectors, measured from the chosen spacetime origin, are orthogonal in the Minkowski inner product. It is invariant under Lorentz transformations about that origin but not under arbitrary translations. It is not a general criterion for their causal separation.
For a concrete example, put and . Their inner product vanishes, but their separation has squared interval , which can be positive, zero or negative. If is timelike, a rest frame for makes ; this means that and the chosen origin are simultaneous in that frame, not that and are simultaneous.

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