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A nineteenth-century explanation of changing therapeutic practice: inflammatory diseases were said to have become less vigorous or more debilitating, requiring less depletion. It competed with explanations based on improved pathology and better evaluation of treatment. This is a historical theory, not a general modern law. ^[ref]

Material that leaves the blood vessels during inflammation. Historical theories of its formation and removal should be distinguished from current pathology.

Contemporary anonymous review, not Alison’s 1856 primary article, despite the catalogue using the same reviewed title. Opening pp. 1–3 contrast the change-of-type theory of disease with changed pathology.