A phosphoinositide is a phosphorylated derivative of phosphatidylinositol. Phosphate position changes the recognition surface of the headgroup, allowing distinct species to recruit different membrane-associated proteins.
A phosphoinositide enriched in particular membrane domains, including Golgi-associated compartments.
phosphatidylinositol 3,5-bisphosphate is a doubly phosphorylated phosphoinositide involved in later endolysosomal organization and function. Perturbing it need not imply that initial surface uptake is defective.
phosphatidylinositol 3-phosphate is a phosphoinositide associated with endosomal membrane identity and recruitment of specific effectors.
phosphatidylinositol 3,4-bisphosphate has phosphates at positions 3 and 4 of the inositol ring. Local production can contribute to timed recruitment of endocytic membrane-remodeling factors.
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